(This Is Not About The System)
Anadamide and 2AG: Pivotal Endocannabinoid Players
Cannabinoids occur in a variety of forms. Phytocannabinoids exist naturally in plants (particularly the cannabis plant). On the other hand, synthetic cannabinoids are synthesized chemically, and endogenous chemicals are created by living organisms' physiological systems.
What is it that they all share in common? They all interact with the endocannabinoid system, which is found in almost all living things. The endocannabinoid system is involved in practically every physiological and psychological activity, including inflammation, metabolism, digestion, and endocrine balance.
How is this accomplished? Although this is a complex system that is currently being researched, the main vital participants in this extraordinary network are 2-arachidonoylglycerol (2-AG) and anandamide (AEA).
Vital endocannabinoid players: 2-AG and AEA
Anandamide and 2-arachidonoylglycerol are two important buzzwords in the cannabis as well as holistic health communities. Both are endogenous (or internally generated) cannabinoid chemicals present in a wide variety of vertebrates and invertebrates.
Many physiological activities in the brain and body are maintained by 2-AG and AEA. They work together to maintain homeostasis throughout the system. This implies that their actions are critical in maintaining the equilibrium of your mind and body. Let's learn more about these endogenous cannabinoids.
Similarities in structure between 2-AG and AEA
The structural shapes of 2-AG and AEA are identical. They both revolve around arachidonic acid (AA). This acid has a carbon chain, as well as hydrogen and two oxygen atoms. AA is a molecule that looks like a hook.
The binding of this AA molecule to a glycerol molecule is required for the synthesis of 2-AG. The term "2-Arachidonoylglycerol" implies this. Glycerol, which you may be familiar with as a constituent of soap, is also a common vehicle for delivering medicinal chemicals. The incorporation of glycerol into the AA molecule is crucial in understanding why 2-AG has a greater affinity for CB receptors than AEA.
How do they work?
Anandamide has received a lot of attention throughout the last decade. The main reason for this is that CBD, the latest herbal sensation, is a natural FAAH (Fatty acid amide hydrolase) inhibitor. Because FAAH inhibition raises levels of AEA circulation in the bloodstream, it is clear that anandamide plays a large part in the advantages observed by CBD users.
So, what exactly does Anandamide do? Anandamide is thought to aid in mood regulation, immunological function, neuroprotection, and other functions. According to conventional wisdom, AEA has a greater influence on the neurological systems, whereas 2-AG has a greater affect on the exterior body.
To begin with, 2-AG concentrations in the human brain can be up to 170 times higher than AEA. When contemplating its potential impact on awareness, that is a substantial figure. Second, whereas AEA has a high affinity for CB1 receptors, it doesn't have the same affinity for CB2 receptors. 2-AG, on the other hand, is a powerful stimulator of both of these receptors. Furthermore, both of these endocannabinoids show affinity for receptors that are linked to but not directly associated with the endocannabinoid network.
Final word
Now you know! This is the basic information about these two buzzwords in the cannabis industry. You are able to benefit from CBD, thanks to 2-AG and AEA.
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